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Spending on ‘orphan drugs’ for kids rose 65% in 5 years

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“Orphan drugs” account for 1 in every 15 private insurance dollars spent on children’s health care, a new study shows.

That’s up 65% from just five years ago.

One in every 170 kids take these medications, which treat rare childhood diseases. Even though insurance companies pay much of the high cost, families’ share of the cost has risen rapidly.

The study shows that out-of-pocket costs for these families exceeded those faced by adults who also take orphan drugs.

Some families spend thousands of dollars each year to buy orphan drugs, which are drugs that have received a special designation from the US Food and Drug Administration. About 1 in 8 families paid more than $2,000 a year in 2018—double the percentage who spent that much in 2013.

The study in Health Affairs looks at private insurer payments and out-of-pocket spending on 526 orphan drugs. Researchers used a database that every year included data about the drug costs of 4.4 to 5.8 million children age 17 and under.

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The special FDA “orphan” designation is designed to incentivize drug companies to develop treatments for rare conditions. A company that receives the designation for its product has a greater amount of time when it has the exclusive rights to market the product and fend off competitors.

The researchers report that prices for small-molecule drugs drove much of the increase in orphan drug spending, with a 162% rise in five years, compared with 16% for biologic drugs, which are derived from living organisms.

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Just three drugs approved for the same condition account for more than 23% of all spending on orphan drugs for privately insured children in 2018, the analysis shows. All three—sold as Norditropin, Humatrope, and Genotropin—were originally developed to boost the height of children with growth hormone deficiency.

But other research has shown that many children who don’t have this rare condition also receive these three drugs through off-label prescribing aimed at boosting their height.

There are no clear guidelines for determining which children should receive the drugs, and insurance companies vary widely in their decisions about covering the cost of the drugs for such uses.

Kao-Ping Chua, a pediatrician and health care researcher at Michigan Medicine, the academic medical center of the University of Michigan, and Rena Conti, of Questrom Boston University School of Business coauthored the work.

Earlier this year, the team published their analysis of all FDA orphan drug designations between 2010 and 2018. They found that just over one-third were for pediatric conditions.

Source: University of Michigan

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